How does xenon produce anaesthesia




















The major volatile anaesthetics are based on chlorofluorocarbons CFCs and are known to deplete the ozone layer; in addition, nitrous oxide is times more potent as a greenhouse gas than carbon dioxide, taking years to break down.

The amount of nitrous oxide released as an anaesthetic contributes 0. The attention that the Xenon Study Group has recently given to xenon anaesthesia is deserved; we have further highlighted its potential clinical applications and exemplary safety record. Xenon has notable pharmacokinetic, cardiostable, neuroprotective and analgesic advantages over other anaesthetics, and further clinical trials are warranted to evaluate its effectiveness in the operating theatre and critical care unit.

As delivery technology develops, xenon will become a more viable option in the anaesthetic armamentarium. Professor Maze is a board member of an Imperial College spin-out company Protexeon Ltd that is interested in developing clinical applications for medical gases, including xenon. Professor Maze is a paid consultant in this activity.

Cullen , SC , Gross EG The anaesthetic properties of xenon in animals and human beings, with additional observations on krypton. Nature , , — Nature , , Anesthesiology , 92 , — Anesthesiology , , — Nat Med. Anesthesiology , 95 , —7.

Trends Neurosci. Anesthesiology , 95 , — Anesthesiology , 98 , 6 — Care Med. Anesthesiology , 31 , —9. Anesthesiology , 94 , — Anesthesiology , 97 , — Stanski DR Monitoring depth of anesthesia. In Miller RD ed. Philadelphia, PA: Churchill Livingstone, — Anesthesiology , 93 , — Anesthesiology , 89 , — Goto T , Nakata Y, Saito H, Ishiguro Y, Niimi Y, Morita S The midlatency auditory evoked potentials predict responsiveness to verbal commands in patients emerging from anesthesia with xenon, isoflurane, and sevoflurane but not with nitrous oxide.

Anesthesiology , 94 , —9. Acta Anaesthesiol. Anesthesiology , 86 , —8. Anaesthesia , 56 , — A prospective, randomized, controlled trial.

Anesthesiology , 85 , — Lancet , , — A comparison with nitrous oxide. Anaesthesia , 45 , —8. A transoesophageal echocardiography and transcranial Doppler sonography study. Anaesthesia , 48 , —9. Ishiguro , Y Cardiovascular effects of xenon. Preckel B , Schlack W, Heibel T, Rutten H Xenon produces minimal haemodynamic effects in rabbits with chronically compromised left ventricular function.

Preckel B , Mullenheim J, Moloschavij A, Thamer V, Schlack W Xenon administration during early reperfusion reduces infarct size after regional ischemia in the rabbit heart in vivo. Anesthesiology , 99 , 90 —6. Anesthesiology , 75 , —7. Sattler R , Tymianski M Molecular mechanisms of calcium-dependent excitotoxicity. Anesthesiology , 96 , — Life Sci. Ma D , Hossain M, Rajakumaraswamy N, Franks NP, Maze M Combination of xenon and isoflurane produces a synergistic protective effect against oxygen—glucose deprivation injury in a neuronal—glial co-culture model.

Anesthesiology , 99 , — Anesthesiology 98 , —8. Blood Flow Metab. Anesthesiology , 87 , — Neuropsychopharmacology , 14 , —7. Neurology , 49 , S 66 —9. Science , , —2. Science , , EMBO J. Anesthesiology , 94 , —7. Stroke , 18 , —8. Anaesthesia , 56 , —9. Acta Neurol. Plougmann J , Astrup J, Pedersen J, Gyldensted C Effect of stable xenon inhalation on intracranial pressure during measurement of cerebral blood flow in head injury. Anesthesiology , 92 , —8.

Yagi M , Mashimo T, Kawaguchi T, Yoshiya I Analgesic and hypnotic effects of subanaesthetic concentrations of xenon in human volunteers: comparison with nitrous oxide.

Fujinaga M , Maze M Neurobiology of nitrous oxide-induced antinociceptive effects. Pain , , 7 — Br J Anaesth ; 89 : — Anesthesiology ; 98 : —8. NMDA receptor function and human cognition: the effects of ketamine in healthy volunteers. Neuropsychopharmacology ; 14 : —7. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits. Nature ; : — Effects on haemodynamics and catecholamine release of xenon anaesthesia compared with total i. Br J Anaesth ; 78 : —7. Xenon has greater inhibitory effects on spinal dorsal horn neurons than nitrous oxide in spinal cord transected cats.

Anesth Analg ; 88 : —7. Ketamine causes a paradoxical increase in the Bispectral Index. Anesthesiology ; 87 : A Anesthesiology ; 85 : A Minimum alveolar concentration MAC of xenon with sevoflurane in humans. Anesthesiology ; 94 : —4. Comparison of inhalation inductions with xenon and sevoflurane. Acta Anaesthesiol Scand ; 41 : — J Clin Anesth ; 11 : — Plasma concentration of fentanyl with xenon to block somatic and hemodynamic responses to surgical incision.

Br J Anaesth ; 69 : —9. A comparative study of the antinociceptive action of xenon and nitrous oxide in rats. Anesth Analg ; 85 : —6. Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs.

Comparison of the analgesic potency of xenon and nitrous oxide in humans evaluated by experimental pain. Br J Anaesth ; 81 : —7. Effect of stable xenon inhalation on intracranial pressure during measurement of cerebral blood flow in head injury.

J Neurosurg ; 81 : —8. Xenon administration during early reperfusion reduces infarct size after regional ischemia in the rabbit heart in vivo. Anesth Analg ; 91 : — Xenon produces minimal haemodynamic effects in rabbits with chronically compromised left ventricular function. Br J Anaesth ; 88 : —9. Rampil IJ. A primer for EEG signal processing in anesthesia.

Rosow C, Manberg PJ. Bispectral index monitoring. Anesthesiol Clin North Am ; 19 : — Xenon does not alter cardiac function or major cation currents in isolated guinea pig hearts or myocytes. Effect of ketamine on bispectral index and levels of sedation. J Clin Monit Comput ; 14 : Anesthesiology ; 96 : — The auditory evoked response as an indicator of awareness.

Br J Anaesth ; 63 : —5. The effect of xenon on spinal dorsal horn neurons: a comparison with nitrous oxide. Anesth Analg ; 84 : —6.

MAC of xenon and halothane in rhesus monkeys. J Neurosurg Anesthesiol ; 6 : —9. Effects of xenon on in vitro and in vivo models of neuronal injury. Analgesic and hypnotic effects of subanaesthetic concentrations of xenon in human volunteers: comparison with nitrous oxide. Br J Anaesth ; 74 : —3. Propofol prevents delayed neuronal death following transient forebrain ischemia in gerbils. Can J Anaesth ; 46 : —8.

Yamakura T, Harris RA. Comparison with isoflurane and ethanol. Sedation and arousal associated with dexmedetomidine infusion. Anesthesiology ; 95 : A Oxford University Press is a department of the University of Oxford.

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Measuring the xenon anaesthetic state. Minimum alveolar concentration. Clinical features. Xenon: no stranger to anaesthesia.

Sanders , R. Corresponding author. Both Professor Franks and Professor Maze are paid consultants in this activity. Oxford Academic.

Google Scholar. Cite Cite R. Select Format Select format. Bekkers, J. USA 88 , — Watkins, J. Download references. Franks, R. Dickinson, S. You can also search for this author in PubMed Google Scholar. Reprints and Permissions.

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